Categories: Medicine

Pliva 433 Pill: Uses, Side Effects, Dosage and FAQs

Pliva 433 is essentially a footprint on a pill that is white in a round shape. The pill contains trazodone hydrochloride as an active ingredient in a dose of 50 mg. Pliva 433 is an antidepressant that belongs to the class of antidepressants called phenylpiperazines. It is used to treat diseases such as depression, insomnia and fibromyalgia.

It works to balance the chemicals in the brain. The Pliva 433 pills are biconvex on one side and cut in half and join on the other side.

Pliva 433 Uses

Trazodone is an antidepressant and is most commonly used in depression. It was
approved by FDA in 1981.

  • Depression
  • Anxiety
  • Fibromylagia
  • Mood disorders
  • Insomnia
  • Sedation

Note: Pliva 433 (Trazodone)  may also be used for conditions other than those listed

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Side Effects

Common side effects associated with the use of Trazodone Hydrochloride (Pilva 433
Pill) are :

  • Nausea
  • Vomiting
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Tiredness
  • Blurred vision
  • Changes in your weight
  • Headache
  • Dry mouth
  • Bad taste in the mouth
  • Muscle pains
  • Stuffy nose
  • Constipation
  • Change in sexual desire or/ and ability

Serious side effects can also occur with Pliva 433 Pill. If you have any of these side
effects, stop taking and call your doctor right away:

  • Ringing in the ears
  • Blood in urine
  • Tremors
  • Nightmares
  • Rash
  • Problems urinating
  • Fever
  • Sore throat
  • Stomach or abdominal pain
  • Shortness of breath
  • Fainting
  • Chest pain
  • Widened
  • Irregular heartbeat
  • Trouble breathing
  • Seizures
  • Vision changes
  • Severe dizziness
  • Eye pain or swelling redness


Before using Pliva 433 Tell your doctor if you have the following conditions

  • If you allergic to this drug.
  • Low or high blood pressure
  • Heart problems
  • History of substance abuse
  • Cancer
  • Mental health disorders
  • Liver problems
  • Diarrhea or vomiting
  • Kidney problems
  • Bipolar disorder
  • Glaucoma
  • Having a history of suicide
  • The risk of suicide is greatest when starting treatment or when increasing or decreasing
    the dose of trazodone.

Pliva 433 Interaction

Types of drugs that are known to interact with trazodone include:

  • Drugs used to treat mental illness, including thioridazine; selective serotonin reuptake
    inhibitors (SSRIs), and MAOIs.
  • Blood thinners, including warfarin, aspirin, and ibuprofen
  • Diuretics
  • Cold, cough, and allergy medications, including dexamethasone.
  • Medications used to treat fungal diseases, such as ketoconazol, itraconazole.
  • Medications used to treat heartburn, including cimetidin and cisapride.
  • Medications used to treat HIV/AIDS, including atazanavir, indinavir, and nelfinavir.
  • Some antibiotics, such as clarithromycin and erythromycin.
  • Some seizure medications, such as carbamazepine, ethosuximide, phenobarbital, and
  • Some heart medications, including sotalol and verapamil


Here are some dosage recommendations

  • The usual recommended  dose for depression is 150 mg daily. However, in some cases
    your physician/doctor may start with a lower dose of 100 mg to reduce the risk of side
  • The usual recommended dose for anxiety is 75 mg daily.
    If your dose is 300 mg daily or less, your doctor will probably tell you to take the single dose
    at bedtime.
  • Since Trazodone can make you sleepy, it can be helpful during sleep if you have sleep

Frequently Asked Questions (FAQs)

1. What is Pliva 433 Pill?

Pliva 433 is basically an imprint on a tablet of Trazodone hydrochloride. And it is
commonly used in depression.

2. What is Pliva 433 Pill used to treat?
It used in the treatment, control and prevention of various medical conditions such as
depression, mood disorders, mental health issues, insomnia and other conditions.

3. How Pliva 433 Pill works?
Trazodone binds to the 5-HT2 receptor, acts as a high-dose serotonin agonist and as a
low-dose serotonin antagonist. As with fluoxetine, trazodone’s antidepressant activity is likely due to the blockade of serotonin reuptake due to inhibition of the serotonin reuptake pump at the presynaptic neuronal membrane.

4. What are the side Effects of Pliva 433 pill (Trazodone Hcl) ?
The most common side effects associated with the use of Trazodone are Nausea,
Vomiting, Diarrhea, Drowsiness, Dizziness, Tiredness, Blurred vision, Changes in your
weight, Headache, Muscle pains and other. Please check above.

5. Is PLIVA 433 pill safe during pregnancy?
PLIVA 433 Pill should be used during pregnancy only if the benefits outweigh the risks
to the fetus. Trazodone is classified in the FDA Pregnancy Category C. This means that
withdrawal symptoms should be monitored in neonates if the drug is used until delivery.

6. Is the Pliva 433 pill safe while breastfeeding?
Limited data indicate that the level of trazodone in milk is low and no side effects are
expected in the breastfed infant, particularly if the infant is older than 2 months or if
doses of 100 mg or less are administered at bedtime.

7. What happens if you overdose a pill of Pliva 433?
Overdose is possible with almost all drugs, including trazodone. An overdose of
trazodone would mean that someone accidentally or intentionally ingested more than
the amount prescribed or recommended. If you have an overdose of Trazodone, it is
important to seek help immediately as this can be extremely dangerous.

8. What should you do if you miss a dose of Trazodone HCL?
Take the missed dose as soon as you remember, and when taking the next dose, skip
the previous dose.

9. Is Pliva 433 a habit forming medicines?
There is no evidence that Trazodone is addictive. However, additional side effects may
occur if you suddenly stop taking it.

10. How do I take it?
You should take Trazodone after meals to reduce the risk of getting sick.

11. Is it safe to drive a vehicle or operate machinery after taking this medicine?
Trazodone can make you sleepy or less alert. Do not drive, ride a bicycle, or use tools
or machines until you know how this medicine affects you.

12. Can Pliva 433 also be used with alcohol?
You can drink alcohol while you are taking Trazodone, but it can make you tired.
It is best if you stop drinking alcohol until you know how you feel about the medicine.



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