4H2 Pill: Identification, Uses, Side Effects, Dose

4H2 Pill

4H2 is an imprint on a white oval shape Tablet. The active ingredient in this tablet is Cetirizine hydrochloride. This belongs to a group of drugs known as Antihistamines. It is much less likely to make you sleepy than other antihistamines.

4H2 Identification

White and oval Pill with Imprint of 4H2

  • Imprint: 4H2
  • Generic: Cetirizine Hydrochloride
  • Brand: Zyrtec
  • Strength: 10 mg.
  • Color: White
  • Form: Tablet
  • Class: Antihistamine

4H2 Pill Uses

As 4H2 Pill Contain Cetirizine which is used to treat allergic symtpoms such as:

Seasonal Allergic Rhinitis

Symptoms include

  • Sneezing,
  • Nasal pruritus,
  • Ocular pruritus,
  • Rhinorrhea,
  • Tearing, and
  • Redness of the eyes

Perennial allergic rhinitis:

Symptoms include

  • Nasal pruritus,
  • Rhinorrhea,
  • Sneezing,
  • Postnasal discharge,
  • Tearing
  • Ocular pruritus, and

Chronic urticaria:

Symptoms include

  • Batches of red or skin-colored.
  • Welts that vary in size, change shape
  • Itching, which may be severe

4H2 Pill Side Effects:

Cetirizine can cause the following side effects

  • Excessive tiredness
  • Drowsiness
  • Stomach pain
  • Dry mouth
  • Vomiting
  • Diarrhea

This is not a complete list of side effects. Tell your doctor about any unexpected side effects that you have while taking cetirizine.


Avoid 4H2 Pill (Cetirizine) and ask your doctor for advice; Avoid if you

  • Have predisposition factors of urinary retention
  • Have liver or kidney problems,
  • Are scheduled for allergy testing.
  • Are an epileptic patient or a patient at risk of convulsions
  • Do not chew, and break cetirizine extended-release tablets and capsules.

4H2 Pill Contraindications

4h2 Pill is contraindicated in the following conditions

  • Hypersensitivity reaction to this drug
  • It is also contraindicated in case of kidney disease.


The recommended dose of cetirizine for treating hay fever, hives or allergies is 5 to 10 mg (milligram). The maximum recommended dose of cetirizine is 10 mg (milligram) daily.

The dose may be based on the following:

  • Other medications you are taking
  • the condition being treated
  • how you respond to this medication
  • your body weight, height, age and gender.

4H2 Pill- Interactions

Tell you doctor about all the medication you are taking including the prescription and over the counter medicine. Cetirizine can interact with the following medicine

  • Bosutinib
  • Ponatinib
  • Lomitapide
  • Lurasidone
  • Lopinavir-ritonavirl
  • Phenelzine
  • Clobazam
  • Ritonavir
  • Vemurafenib
  • Crizotinib

This is not a complete list of medicine that interact with 4H2 pill. Tell your doctor about the drugs you are already taking.

Frequently Asked Questions

1. What is the 4H2 pill?

The pill 4H2 is an oval tablet that belongs to the group of antihistamines. The main component of this medicine is cetirizine hydrochloride. This medicine is used to treat diseases such as hay fever, seasonal allergies, allergic rhinitis, urticaria and hives.

2. How does the 4H2 pill work?

It works by blocking the histamine produced by the body during an allergic reaction. Histamine can cause sneezing, itching, tearing and cold symptoms.

3. How should I take the pill 4H2 (cetirizine)?

Take cetirizine exactly as indicated on the label or as prescribed by your doctor. Do not use it in larger quantities or longer than recommended. You can take cetirizine with or without food.

4. What happens if I miss a dose of 4H2 pill?

Take the missed dose as soon as you remember. When it is almost time to take the next dose, wait for the medicine to be taken and skip the missed dose. Do not take any additional medicines to make up for the missed dose.

5. What happens with an overdose of Cetirizine (Pill 4H2)?

If you think you have taken too much of this medicine, contact an ambulance. The symptoms of overdose may include restlessness or nervousness and you want to sleep.

6. What should I avoid?

If you are taking regular medications that make you sleepy (eg, cold or allergy medicines, narcotics, sleeping pills, muscle relaxants and anticoagulants, depression or anxiety), talk to your doctor. They can worsen the drowsiness caused by cetirizine. Cetirizine may cause side effects that may affect your thinking or reactions. Be careful when driving or doing something that needs to be alert and alert. Avoid drinking alcohol. It can intensify some of the side effects of cetirizine.

7. Can I take the 4H2 pill during pregnancy?

If you are pregnant or planning to become pregnant, talk to your doctor before taking cetirizine. Cetirizine is usually not recommended during pregnancy.

8. Can I take Cetirizine (4H2 tablet) while breastfeeding?

It is not recommended to breastfeed your baby. This is because the drug passes into breast milk.

9. Can I drive or operate machinery after taking the 4h2 pill?

Do not drive or use machines when you are sleepy. At the recommended dose, these tablets do not cause drowsiness in most patients.

10. How to store cetirizine hydrochloride (4H2 tablet)?

Keep this medicine out of the sight and reach of children. Do not take the tablets after the expiry date indicated on the blister and on the package. The expiry date refers to the last day of that month. Do not dispose of medicines on waste water or waste. Ask your pharmacist to remove the drugs you no longer use. These measures contribute to protecting the environment.

Next Imprint: Pliva 433

How long does methadone stay in your system?

How long does methadone stay in your system ?
How long does methadone stay in your system depends on many factors such as age, weight, metabolism, liver function and other diseases, as well as the duration of methadone use, frequency of use, dose level and concomitant use of other substances.


Methadone belongs to a group of medications called opioids. It was created by German doctors during the Second World War. When he arrived in the United States, he used to treat extremely painful people. Today, the doctor can use it for the treatment of heroin addiction or narcotic analgesics.
It works a lot like morphine. You can take it as a tablet, powder or liquid. It must be prescribed by a doctor. People who take it illegally often inject it, exposing them to diseases such as HIV. Although safer than other narcotics, your doctor should monitor you while taking methadone. Consumption can be addictive or abusive.
Like other opioids, it works by changing how the brain and the rest of the nervous system respond to pain. Since methadone is a synthetic opioid, there is a risk of drug abuse in case of abuse. As the National Institute of Addiction explains, the regular use of an addictive substance causes physical dependence, a natural process of adaptation to the continued presence of the drug.

Methadone Uses

Your doctor may prescribe methadone for the following conditions

  • Severe pain from chronic illness, an injury, or surgery, or .
  • For the treatment of dry cough.
  • Treatment for addiction to other opioids.

How long does methadone stay in your system?

How long does methadone stay in your system depends on its dose, and its metabolism.

Many factors influence how long methadone stays in your system. Individual health factors such as age, weight, metabolism, liver function and other conditions, as well as duration of methadone use, frequency of administration, dosage and use All other substances influence the rate of methadone treatment. The clinical duration of methadone in your system is between 2 and 13 days. Methadone is an effective drug that remains active long after the loss of its analgesic effects.

The US Food and Drug Administration has found that relieving methadone pain can take four to eight hours, but it may take 8 to 59 hours to completely cleanse the body.

The half-life of methadone was 24 to 36 hours. We measure the disappearance of a medicine in the blood with a concept of “half-life”.

Half Life

Half life is the time needed to reduce the amount of drugs in the blood by half. While methadone is typically processed out of your system within two weeks, The traces of the methadone may appear much longer depending on the type of test used. Employers, drug treatment programs, sports organizations and law enforcement agencies can request a methadone drug test.

While standard screening tests often detect the use of opioids such as heroin and morphine, they do not recognize the use of methadone. For this reason, if the screening test is to investigate the presence of methadone, specific and more expensive tests must be used. Urine, saliva, hair and blood tests have been developed to detect the presence of methadone in the system.

Here is How long does methadone stay in your system?

  • Urine tests can detect methadone after 24 hours and up to 7 days.
  • Saliva tests can detect methadone within 10 minutes of use and up to 10 days.
  • Hair tests can detect methadone within 7 to 10 days after application and up to 90 days.
  • Blood tests should be performed within 3 hours to reach the maximum dose, but can be detected as early as 3 hours after oral administration.  Blood tests can detect methadone for up to 2.5 days.

Methadone Overdose

Following are some of the symptoms of Overdose from this drug. These include

  • Sleepiness;
  • Slowed breathing;
  • Slowed heart rate.
  • Muscle weakness;
  • Clammy skin;
  • Cold,
  • Changes in the size of pupils

If you think you or someone has overdosed on methadone, get emergency help right away.

Factors that Influence How long does methadone stay in your system?

These factors include

  • Patient’s metabolic rate,
  • Genetics of Patient.
  • Level of liver functioning,
  • Kidney functions
  • Weight,
  • Height, and
  • Food intake over the relevant time period.


To understand How long does methadone stay in your system you must know the half-life of methadone. It varies a lot as follows: 24 to 36 hours, 13 to 47 hours, 15 to 40 hours and 8 to 59 hours. Since the widest window is between 8 and 59 hours and covers all other possibilities, it is certainly considered the most accurate window. In days, a half-life of 8 to 59 hours means 1 to 13 days. In other words, a person can keep methadone in the body for 1-13 days.

You can also check out How long does adderall stay in your system ?

How long does adderall stay in your system?

How Long Does Adderall Stay in Your System?

How long does adderall stay in your system depends on many factors, including age and weight. Adderall is a combination of amphetamines and dextroamphetamine. It belongs to the class of stimulants of the central nervous system. Adderall is used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy.

Adderall works by changing the levels of some natural substances in the brain. Adderall can help you increase your attention span, focus on one activity and control your behavioral problems. If you take adderall, you may be wondering How long does adderall stay in your system?

How long it takes for a medicine to leave your body depends on your dose and your metabolism. We measure the disappearance of a drug from the bloodstream with the concept of “half-life”

What is a Half Life?

It is defined as the time needed to reduce the plasma concentration of the drug or the total amount in the body by 50%. In other words, after a half-life, the concentration of the drug in the body is half of the initial dose. It may sound complex, but actually quite simple.

How long does adderall stay in your system?

The half-life of amphetamine depends on the isomer.

  • Half life for l-amphetamine the half-life is reported to be of 11-14 hours.
  • The half life For d-amphetamine is approximately 9-11 hours

While The half-life of dextroamphetamine is 11 hours in teens aged 13 to 17 and 9 hours in children aged six to 12 and 10 hours in adults.

Here is How long does adderall stay in your system?

Adderall has a half-life of 9 to 14 hours, which means that only half of the medicine remains in your body for 9 to 14 hours after administration. Adderall will completely drain your system in 3-4 days.

Adderall can be detected with the help of urine test, Hair testing, Saliva testing, and blood testing.

  • Adderall will stay in your saliva for upto 72 hours.
  • The complementary urine test may show positive results about 2 to 4 days after ingestion.
  • Adderall may produce a peak plasma concentration approximately six hours after ingestion.
  • Hair tests also showed traces of Adderall one month after taking the dose. On average, Adderall moves away from hair within 90 days.

Note: We make a hypothesis in medicine. It’s not accurate, but close enough. We say that the drug practically disappeared after 4-5 half-lives. If the drug has a half-life of 3 hours, it is almost used up 12 to 15 hours after the last dose. The effect of the drug may have disappeared, although some drugs are still in the blood.

What is the drug Adderall used for?

Adderall is the brand name of a prescription medication used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy.

Factors that Influence How Long Adderall Stays in Your System

A number of factors influence the length of time Adderall remains in your system. These factors include the following

  • Age
  • Body composition
  • Food in the system
  • PH levels
  • Metabolism
  • Organ function such as liver and kidney
  • Dosage amount
  • Frequency of use
  • Hydration levels
  • The person’s genetics


Adderall has a half-life of 9 to 14 hours. This means that only half of the medication stays in your body 9 to 14 hours after administration. Adderall will completely empty your system in 3-4 days.

Femara Side Effects, Uses, And Dosage

Femara Side Effects Uses, Dosage

Femara is the brand name of Letrozole. Femara belongs to a group of medicine known as aromatase inhibitors.

Femara Tablet is used to treat certain types of breast cancer  (hormone receptor-positive breast cancer) in postmenopausal women. Letrozole is also used to prevent recurrence of cancer.

Some breast cancers are accelerated by a natural hormone called estrogen. Letrozole reduces the amount of estrogen produced by the body. This reduction in estrogen helps to slow down or reverse the growth of these breast cancers.


Femara Side Effects:

Like any other medicine, Femara can cause some side effects along with its beneficial effects. Some Femara Side effects are common and some are Rare. Some Femara Side Effects are More serious than other and need medical attention.

The most common Femara Side effects were

  • Hot flashes,
  • Flushing,
  • Asthenia,
  • Arthralgia;
  • Edema,
  • Headache,
  • Hypercholesterolemia,
  • Dizziness,
  • Sweating,
  • Musculoskeletal
  • Bone pain

Note: The occurence of the above side effects are greater than 20%.

Less common Femara Side effects include

  • High blood pressure,
  • Tachycardia,
  • Palpitation,
  • Dyspnea,
  • Cough,
  • Anxiety,
  • Memory impairment,
  • Urticaria,
  • Insomnia,
  • Taste disturbance,
  • Dry skin,
  • Abdominal pain,
  • Pruritis,
  • Urinary frequency,
  • Thrombophlebitis,
  • Viginal discharge,
  • Urinary tract infection,
  • Vigina bleeding,
  • Breast pain,
  • Cataract,
  • Pyrexia,
  • Blurred vision,
  • Leucopenia,
  • Carpal tunnel syndrome,
  • Eye irritation,
  • Tumor pain,
  • Arthritis and
  • General edema.

Rare Femara side effects

Very rare Femara side effect includes:

  • Cerebrovascular infarction,
  • Arterial thrombosis and
  • Embolism.

Long Term Femara Side Effects

  • Femara may cause decreases in bone mineral density (BMD).
  • Femara can cause fetal harm and is contraindicated for use in pregnant women.
  • Liver Cirrhosis.

Note: This is not a complete list of Femara side effects. Stop using This drug and Consult your doctors if You experience the above effects or other serious side effects.


  • The recommended standard dose of letrozole for all types of breast cancer treatment is 2.5 mg per day.
  • The duration of treatment is usually 5 years, but some doctors recommend it for a longer period.
  • If you think you have forgotten a dose of letrozole, try it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
  • You can take without regard to meals.


Disclaimer: The Article above is not intended to replace a medical opinion, diagnosis or treatment by a health professional. Always ask your doctor or another qualified practitioner if you have questions about a health problem.

PLIVA 433 pill: Uses, Side Effects, Dosage, FAQs

Pliva 433

Pliva 433 is essentially a footprint on a pill that is white in a round shape. The pill contains trazodone hydrochloride as an active ingredient in a dose of 50 mg.

Pliva 433 is an antidepressant that belongs to the class of antidepressants called phenylpiperazines. It is used to treat diseases such as depression, insomnia and fibromyalgia.

It works to balance the chemicals in the brain.

The tablets are biconvex on one side and cut in half and join on the other side.

Pliva 433 Uses

Trazodone is an antidepressant and is most commonly used in depression. It was approved by FDA in 1981.

  • Depression
  • Anxiety
  • Mood disorders
  • Insomnia
  • Sedation
  • Fibromylagia

Note: Pliva 433 (Trazodone)  may also be used for conditions other than those listed above.

Pilva 433 Pill Side Effects

Common side effects associated with the use of Trazodone Hydrochloride (Pilva 433 Pill) are :

  • Nausea
  • Vomiting
  • Diarrhea
  • Drowsiness
  • Dizziness
  • Tiredness
  • Blurred vision
  • Changes in your weight
  • Headache
  • Muscle pains
  • Dry mouth
  • Bad taste in the mouth
  • Stuffy nose
  • Constipation
  • Change in sexual desire or/ and ability

Serious side effects can also occur with Pliva 433 Pill. If you have any of these side effects, stop taking and call your doctor right away:

  • Ringing in the ears
  • Nightmares
  • Blood in urine
  • Tremors
  • Problems urinating
  • Fever
  • Shortness of breath
  • Sore throat
  • Stomach or abdominal pain
  • Fainting
  • Chest pain
  • Widened
  • Trouble breathing
  • Irregular heartbeat
  • Seizures
  • Vision changes
  • Severe dizziness
  • Eye pain or swelling redness
  • Rash


Before using Pliva 433 Tell your doctor if you have the following conditions

  • If you allergic to this drug.
  • Low or high blood pressure
  • Heart problems
  • History of substance abuse
  • Cancer
  • Mental health disorders
  • Liver problems
  • Diarrhea or vomiting
  • Kidney problems
  • Bipolar disorder
  • Glaucoma
  • Having a history of suicide

The risk of suicide is greatest when starting treatment or when increasing or decreasing the dose of trazodone.

Pliva 433 Interaction

Types of drugs that are known to interact with trazodone include:

  • Drugs used to treat mental illness, including thioridazine; selective serotonin reuptake inhibitors (SSRIs), and MAOIs.
  • Blood thinners, including warfarin, aspirin, and ibuprofen
  • Diuretics
  • Cold, cough, and allergy medications, including dexamethasone.
  • Medications used to treat fungal diseases, such as ketoconazol, itraconazole.
  • Medications used to treat heartburn, including cimetidin and cisapride.
  • Medications used to treat HIV/AIDS, including atazanavir, indinavir, and nelfinavir.
  • Some antibiotics, such as clarithromycin and erythromycin.
  • Some seizure medications, such as carbamazepine, ethosuximide, phenobarbital, and phenytoin.
  • Some heart medications, including sotalol and verapamil


The usual dose for depression is 150 mg daily. However, in some cases your doctor may start with a lower dose of 100 mg to reduce the risk of side effects.

The usual recommended dose for anxiety is 75 mg daily.

If your dose is 300 mg daily or less, your doctor will probably tell you to take the single dose at bedtime.

Since Trazodone can make you sleepy, it can be helpful during sleep if you have sleep problems.

Frequently Asked Questions (FAQs)

1. What is Pliva 433 Pill?

Pliva 433 is basically an imprint on a tablet of Trazodone hydrochloride. And it is commonly used in depression.

2. What is Pliva 433 Pill used to treat? 

It used in the treatment, control and prevention of various medical conditions such as depression, mood disorders, mental health issues, insomnia and other conditions.

3. How Pliva 433 Pill works?

Trazodone binds to the 5-HT2 receptor, acts as a high-dose serotonin agonist and as a low-dose serotonin antagonist. As with fluoxetine, trazodone’s antidepressant activity is likely due to the blockade of serotonin reuptake due to inhibition of the serotonin reuptake pump at the presynaptic neuronal membrane.

4. What are the side Effects of Pliva 433 pill (Trazodone Hcl) ?

The most common side effects associated with the use of Trazodone are Nausea, Vomiting, Diarrhea, Drowsiness, Dizziness, Tiredness, Blurred vision, Changes in your weight, Headache, Muscle pains and other. Please check above.

5. Is PLIVA 433 pill safe during pregnancy?

PLIVA 433 Pill should be used during pregnancy only if the benefits outweigh the risks to the fetus. Trazodone is classified in the FDA Pregnancy Category C. This means that withdrawal symptoms should be monitored in neonates if the drug is used until delivery.

6. Is the Pliva 433 pill safe while breastfeeding?

Limited data indicate that the level of trazodone in milk is low and no side effects are expected in the breastfed infant, particularly if the infant is older than 2 months or if doses of 100 mg or less are administered at bedtime.

7. What happens if you overdose a pill of Pliva 433?

Overdose is possible with almost all drugs, including trazodone. An overdose of trazodone would mean that someone accidentally or intentionally ingested more than the amount prescribed or recommended. If you have an overdose of Trazodone, it is important to seek help immediately as this can be extremely dangerous.

8. What should you do if you miss a dose of Trazodone HCL?

Take the missed dose as soon as you remember, and when taking the next dose, skip the previous dose.

9. Is Pliva 433 a habit forming medicines?

There is no evidence that Trazodone is addictive. However, additional side effects may occur if you suddenly stop taking it.

10. How do I take it?

You should take Trazodone after meals to reduce the risk of getting sick.

11. Is it safe to drive a vehicle or operate machinery after taking this medicine?

Trazodone can make you sleepy or less alert. Do not drive, ride a bicycle, or use tools or machines until you know how this medicine affects you.

12. Can Pliva 433 also be used with alcohol?

You can drink alcohol while you are taking Trazodone, but it can make you tired.

It is best if you stop drinking alcohol until you know how you feel about the medicine.

Also Read 8 Nursing Things Every Nurse should Have

Phosphodiesterase inhibitors: Types, Uses, Side Effects

Phosphodiesterase inhibitors

Phosphodiesterase Inhibitors are a class of drugs that inhibit phosphodiesterase (PDE) enzymes. PDEs normally break down phosphate groups and lower cAMP or cGMP into target cells.

PDE inhibitors are classified according to the enzymes for which they act as non-specific inhibitors of PDE5, PDE4 and PDE3.

Inhibitors of PDE3 have positive inotropic, vasodilatory and antiplatelet effects used in acute heart failure and peripheral vascular disease. PDE3 inhibitors are not recommended for long-term use because of their strong cardiostimulatory effect in patients with heart failure.

PDE4 inhibitors allow bronchial dilatation in severe COPD.

PDE5 inhibitors cause pulmonary vasodilation and slackening of the smooth muscle of the penis. They are used in pulmonary arterial hypertension and erectile dysfunction. Nitrates or alpha-blockers are highly contraindicated in patients taking PDE5 inhibitors because of the risk of life-threatening hypotension.

Phosphodiestrerase inhibitors are classified into PDE3 and PDE5 inhibitors

  • PDE3 inhibitors
    • Milrinone
    • Amrinone
    • Cilostazol
  • PDE5 inhibitors
    • Sildenafil
    • Tadalafil
    • Verdinafil
    • Udenafil

Phosphodiesterase Inhibitors Type 3 (PDE3 Inhibitors)


Some key highlights of this Phosphodiestrerase inhibitors class are

  • Milrinone is used for the treatment of congestive heart failure
  • Amrinone is Used in the treatment of congestive heart failure.
  • For the reduction of symptoms of intermittent claudication (pain in the legs that occurs with walking and disappears with rest).

1. Milrinone

It is a vasodilator used as a short-term treatment for treat life-threatening heart failure.  Milrinone belongs to a group of drugs called inotropes, which work by helping the heart pump more blood through the body.


Milrinone is used in the treatment of congestive heart failure.

Side Effects

Common side effects of milrinone include

  • Abnormal heart rhythm, and
  • Headache.
  • Dizziness or fainting.
  • Easy bruising or bleeding.
  • Tremors

Less common and more serious side effects include

  • feeling like you might pass out,
  • chest pain,
  • low potassium
  • bronchospasm (wheezing, chest tightness, trouble breathing)

Consult Your doctor if you have the above side effects.


  • Do not drive or operate heavy machinery until you know how milrinone affects you.
  • Get out of bed slowly to avoid dizziness or fainting.

 2. Amrinone

Amrinone (or inamrinone) is a type 3 pyridine phosphodiesterase inhibitor. Amrinone is a positive inotropic cardiotic with vasodilating properties.


Phosphodiesterase 3 inhibitor activity and how to stimulate the influx of calcium ions into the heart cell. Amrinone is an inhibitor of phosphodiesterase (PDE3), leading to an increase in cAMP and cGMP, resulting in increased calcium input, as caused by beta-agonists, resulting in an increased inotropic effect. The main route of excretion in humans is urine, both by inamrinone and by various metabolites (N-glycolyl, N-acetate, glucuronide and N-glucuronide). The chemical interaction with precipitates occurs with amrinone and dextrose or furosemide. Therefore, the mixture of drugs should be avoided.


It is used in the treatment of

  • congestive heart failure.

Side Effects

Common side effects of amrinone include

  • Upset stomach,
  • Lowered platelet counts, and
  • A sudden drop in blood pressure (hypotension).

3. Cilostazol

Cilostazol is an antiplatelet aggregate and a vasodilator. It works by preventing blood cells, called platelets, from clumping together and preventing the formation of harmful clots. It also dilates the blood vessels in the legs. Cilostazol helps the blood to move more easily and ensures the fluidity of blood in your body. Inhibition of platelet aggregation and vasodilation are important mechanisms of cilostazol, used to treat intermittent claudication in peripheral arterial disease. Cilostazol appears to have less cardiostimulant effects than milrinone.


Cilostazol is used to improve the symptoms of a certain blood flow problem in the legs

  • intermittent claudication
  • Cilostazol can decrease the muscle pain/cramps that occur during exercise/walking.

Side Effects

The most common adverse effects of cilostazol are:

  • abdominal pain,
  • abnormal stoolheadache,
  • diarrhea,
  • nausea,
  • upper respiratory tract infections,
  • fluid retention,
  • abnormal heartbeats.
  • dizziness and
  • runny nose.

Phosphodiesterase Inhibitors Type 5 (PDE5 Inhibitors)


  • These drugs are Used for the treatment of erectile dysfunction
  • They are also used for pulmonary hypertension.

1. Sildenafil

Sildenafil belongs to a group of drugs known as Phosphodiesterase Inhibitors type 5 (Phosphodiesterase 5 inhibitors) and  is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, sildenafil works by increasing blood flow to the penis to help a man get and keep an erection.


It is most commonly used for two primary conditions such as

  • Erectile dysfunctions
  • Pulmonary hypertension

Side Effects

The most common side effects include:

  • Nasal congestion
  • Headaches
  • Indigestion
  • Impaired vision
  • Photophobia, or sensitivity to light

Less commonly, some users have experienced cyanopsia, where everything appears to have a tinted blue tinge.

2. Tadalafil

It is in a class of drugs called Phosphodiesterase Inhibitors type-5 (PDE5) inhibitors that also includes sildenafil and vardenafil.


Tadalafil is an oral drug that is used for

  • Treating impotence (the inability to attain or maintain a penile erection) and
  • Benign prostatic hyperplasia (BPH).

Side Effects

The most common side effects of tadalafil are

  • headaches,
  • facial flushing
  • stomach upset,
  • blurred vision,
  • flu-like symptoms, and
  • nausea.
  • diarrhea,
  • abnormal ejaculation.
  • Tadalafil also may cause low blood pressure,
  • changes in color vision

3. Verdenfil

This drug also belongs to a group of drugs known as Phosphodiesterase Inhibitors type -5 (PDE5) inhibitors. Other agents of this group are sildenafil and udenafil. The mechanism of action is same as that of sildenafil.


It is used in the treatment of

  • Erectile dysfunction

Side Effects

Common side effects include

common side effects include:

  • Headache
  • stuffy or runny nose
  • dizziness
  • flushing
  • stomach upset

Celestamine: Uses, Side Effects, Dosage etc


Celestamine is the brand name for the combination of two active ingredients like Betamethasone and dexchlorpheniramine maleate.

Betamethasone belongs to a group of drugs known as Corticosteriods.

Dexchlorpheniramine belongs to a group of drugs known as antihistamines and they are used in allergies and common cold etc.

The composition of these two components in each tablet is below:

  • Betamethasone: 250 mcg per tablet
  • Dexchlorpheniramine Maleate – 2 mg per tablet

It is most commonly used for Arthritis, Itch or rash, Allergic disorders, Skin inflammation, Ataxia telangiectasia, Scalp psoriasis,  Ulcerative colitis and other conditions. Celestamine Tablet may also be used for purposes not listed here.

Celestamine Uses

These Tablets are used to treat, control, prevent and improve the following diseases, conditions and symptoms:
  • Allergic disorders
  • Itching or rash
  • Atopic dermatitis (eczema)
  • Contact dermatitis
  • Breathing disorders
  • Cerebral edema
  • Arthritis
  • Skin inflammation
  • Ataxia telangiectasia
  • Phimosis
  • Scalp psoriasis
  • Blood disorders.
  • Hay fever
  • Ulcerative colitis
  • Hematologic disorders such as Acquired (autoimmune) hemolytic anemia, Diamond-Blackfan anemia, idiopathic thrombocytopenic purpura in adults.

Mechanism Of Action

It is the combination of anti-inflammatory and anti-allergic medications.

  • Betamethasone is a corticosteroids drug, sometimes referred to as steroid. It reduce the amount of inflammatory chemicals your body produces. They also reduce the body’s natural immune response, which helps to control inflammation.
  • while dexchlorophenamine maleate has antihistamine properties.

Celestamine Side Effects

The more common side effects that can occur with Celestamine include:

  • swelling,
  • Rapid weight gain,
  • Problems with your vision;
  • shortness of breath;
  • severe depression,
  • unusual thoughts or behavior,
  • Bloody or tarry stools,
  • Coughing up blood;
  • Sedation and drowsiness
  • seizure (convulsions);
  • Congestive heart failure in susceptible patients
  • Fluid and electrolyte disturbance in body
  • Muscle weakness, loss of muscle mass, tendon rupture.
  • Skin discoloration (Blue skin color).
  • Osteoporosis, pathological fractures
  • Peptic ulcers, irregular bowels, nausea, vomiting
  • Seizure
  • Impaired healing of wounds
  • Thin and fragile skin
  • Swelling of your face, lips, tongue, or throat.
  • Abdominal distention.
  • Increased sweating,
  • urticaria.
  • headaches.
  • Vertigo,
  • Infection. Signs may include:cough, fever, chills.
  • Menstrual irregularities
  • Euphoria, mood swings, depression.

Note: This is not the complete list of side effect. If you feel other and more serious side effects contact your doctor as soon as possible.

Interactions with other drugs

It may interact with the following drugs and products:
  • Amphotericin B
  • Anticholinesterases
  • Antidiabetics
  • Aminoglutethimide
  • Barbiturates
  • Cholestyramine
  • Carbamazepine
  • Cyclosporine
  • Estrogens
  • Digoxin

Warnings & Precautions

Avoid using Celestamine if you

  • Allergy to one of the active ingredients (betamethasone or dexchlorpheniramine maleate).
  • If you have a yeast infection in any part of your body, tell your doctor about the disease and medications you are taking before taking celestamine tablets.
  • Many drugs interact with steroids and cause serious side effects.
  • If you have liver problems, kidney disease, diabetes, tuberculosis, osteoporosis, glaucoma, eye infections with herpes, cataracts, thyroid problems, stomach problems (ulcers, bleeding, etc.), diverticulitis, ulcerative colitis, breast cancer, heart problems, depression, depression, metallic pain If any of these conditions are present, it may be necessary to avoid or adjust the dosage accordingly.
  • The use of steroids can alter the immune system and make you more vulnerable to diseases and infections. Consult your doctor if you notice any signs of infection or discomfort while taking Celestamine.
  • Celestamine can harm an unborn baby or a baby. Steroids can affect a child’s growth. Consult a doctor before using Celestamine during pregnancy or breastfeeding.

Dosage of Celestamine

The usual dose  recommended for adults is 2 to 6 tablets daily. As the patient improves, the dose should be gradually reduced to the required minimum. The medication should stop, Whenever possible. Your doctor will choose the dose that best suits your needs. Your general health may affect your dose. Tell your doctor about any health problems you have before giving him the medicine.

Frequently Asked Questions

1. Should I take Celestamine tablet on an empty stomach before or after meals?

Answer: Celestamine should be used every day according to the doctor’s instructions. It is generally used after meals and before bedtime.

2. What are the uses of Celestamine?

Answer: Celestamine Tablet is used to treat, control, prevent, inflammation, allergic reactions, rashes and many other diseases. Check the uses above.

3. Can Celestamine Tablet be used to combat itching, rashes and allergies?

Answer: Yes, itching, rashes and allergies are among the most commonly reported applications by Celestamine Tablet. Always ask your doctor for advice before using it.

4. Is it safe to use Celestamine Tablet if you are pregnant?

Answer: This is a category C drug. There are no controlled data in pregnant women. Betamethasone has passed the placenta. Betamethasone is recommended only during pregnancy when there are no alternatives and the benefits outweigh the risks. Ask your doctor for specific recommendations for each case.

5. Are Celestamine tablets safe during breastfeeding?

Answer: It is not safe to breastfeed or intend to breastfeed. The corticosteroid can damage the fetus or the baby. It can also interfere with the normal growth of a newborn. Ask your doctor.

6. Can i drive after taking Celestamine Tablet?

Answer: you should not drive if you are taking the medicine, have drowsiness, dizziness or blood pressure is falling. Always ask your doctor what recommendations apply to your body and health.

7. Can I stop taking Celestamine immediately or do I have to stop the application slowly?

Answer: some drugs can not be stopped immediately because of their rebound effects. Ask your doctor for recommendations on your body, your health and other medicines you may use

8. Is this substance or product addiction or is it a habit?

Answer: No, it’s not a habit forming drug.

9. Is Celestamine a steroid?

Answer: Yes, it contains betamethasone, which belongs to a group of medications called corticosteroids.

10. What if I miss a dose of Celestamine?

Answer: If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for the next dose, skip the missed dose and take the usual dose as planned. Do not take the double dose.

11. What should I do in case of an emergency or overdose of Celestamine?

Answer: In case of an emergency or overdose, contact the local ambulance or go to the nearest emergency room.

12. How should I take Celestamine?

Answer: The usual dose for adults is 2 to 6 tablets a day. As the patient improves, the dose should be gradually reduced to the required minimum. Always consult your doctor before taking the medicine.

13. Is celestamine an antihistamine?

Answer: It contains betamethasone as an active ingredient. It is  in a group of medications called corticosteroids. However it also contain dexchlorphenramine in a very minute amount which is an antihistamine.

14. What are the side effects of Celestamine?

Answer: The most common side effects seen with this medicine are headache, nausea, difficulty sleeping, stomach ulcers, loss of appetite, diarrhea and more. This is not a complete list of side effects. For other controls, see above.

15. How to store Celestamine?

Answer: This should be stored at room temperature and protected from light and direct moisture. To avoid damaging the medication, you should not keep it in the bathroom or in the freezer. It is important to check the storage instructions on the product packaging or to ask the pharmacist how many brands of Celestamine are available.

16. When not to use Celestamine Tablet?

Tablet should not be use in case of hypersensitivity reaction to this drug . It is also contraindicated in case of  Idiopathic thrombocytopenic purpura.

17. What is the composition of Celestamine Tablet?

It is the combination of Betamethasone and Dexchlorphenramine. Check above for proportion of each ingredient in this formulation.

18. What happen if i take expired Medicine?

Taking a single dose of an expired Celestamine tablet is unlikely to result in an adverse event. Please consult your doctor or pharmacist for advice or to feel unwell or ill. The expired medicines may become ineffective in the treatment of your prescribed conditions. For safety reasons it is important not to use expired medicines.

19. is celestamine over the counter?

It is a prescription drug and is not available as in over the counter medication.